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MITOMAP: a human mitochondrial genome database--1998 update

A M Kogelnik1, M T Lott, M D Brown

  • 1Center for Molecular Medicine, Emory University School of Medicine, 1462 Clifton Road, Suite 420, Atlanta, GA 30322, USA.

Nucleic Acids Research
|February 21, 1998
PubMed
Summary

MITOMAP, a human mitochondrial DNA (mtDNA) database, has been enhanced with improved interlinking of genetic information. This update provides a valuable resource for mitochondrial biologists and serves as a model for genomic data management.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • MITOMAP is a comprehensive database for human mitochondrial DNA (mtDNA).
  • It integrates information on genome structure, function, mutations, and variations.
  • The need for integrated genomic information is increasing with large-scale sequencing projects.

Purpose of the Study:

  • To document the recent updates and improvements to the MITOMAP database.
  • To highlight the enhanced interlinking of information within MITOMAP.
  • To showcase MITOMAP as a model for genomic information systems.

Main Methods:

  • Continued development of the MITOMAP database.
  • Utilized the generalized information management system, GENOME, for enhanced interlinking.

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  • Focused on integrating human mitochondrial DNA sequence data.

    • Main Results:

    • Increased interlinking of MITOMAP information on the webpage.
    • Enhanced data retrieval and integration capabilities for human mtDNA.
    • Strengthened MITOMAP as a reference for mitochondrial biology.

    Conclusions:

    • MITOMAP serves as a crucial resource for mitochondrial DNA research.
    • The GENOME system facilitates comprehensive data integration.
    • MITOMAP provides a valuable model for developing other human genome information systems.