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Compilation of human mtDNA control region sequences

O Handt1, S Meyer, A von Haeseler

  • 1Zoologisches Institut, Universität München, Luisenstrasse 14, D-80333 München, Germany.

Nucleic Acids Research
|February 21, 1998
PubMed
Summary

This study organizes human mitochondrial DNA control-region sequences into a publicly accessible database. The database includes hypervariable regions I and II (HVRI and HVRII) for genetic research.

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Area of Science:

  • Genetics
  • Bioinformatics
  • Molecular Biology

Background:

  • Human mitochondrial DNA (mtDNA) control regions are crucial for population genetics and evolutionary studies.
  • Organized and accessible sequence data are essential for advancing research in these fields.

Purpose of the Study:

  • To describe the organization of a comprehensive database for human mitochondrial control-region sequences.
  • To make this valuable genetic data readily available to the scientific community.

Main Methods:

  • Data compilation into three ASCII files: hypervariable region I (HVRI), hypervariable region II (HVRII), and associated individual information.
  • Sequence alignment for both HVRI and HVRII regions.

Main Results:

  • The database currently contains 4079 HVRI sequences and 969 HVRII sequences.
  • Sequence data for both HVRI and HVRII are available for 728 individuals.
  • The database is accessible via the World Wide Web.

Conclusions:

  • A well-organized database of human mitochondrial control-region sequences has been established.
  • This resource facilitates research in human genetics, evolution, and population studies.

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