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The Organelle Genome Database Project (GOBASE)

M Korab-Laskowska1, P Rioux, N Brossard

  • 1Département de Biochimie, Université de Montréal, Montréal, Québec H3C 3J7, Canada.

Nucleic Acids Research
|February 21, 1998
PubMed
Summary
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The Organelle Genome Database (GOBASE) integrates diverse organelle data, focusing on mitochondrial sequences and genetic maps for eukaryotic species. This publicly accessible web resource supports complex comparative genomics queries.

Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Organelle genomes (mitochondria and chloroplasts) contain vital genetic information.
  • Integrating diverse organelle data is crucial for comparative genomics.
  • Existing databases may lack comprehensive or integrated organelle genetic information.

Purpose of the Study:

  • To present the Organelle Genome Database (GOBASE) as a comprehensive resource.
  • To focus on organizing and integrating mitochondrial genome data.
  • To facilitate complex biological and comparative genomics queries.

Main Methods:

  • Implementation as a relational database.
  • Development of a web-based user interface.
  • Creation of custom software for data population, validation, and standardization.

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Main Results:

  • GOBASE currently focuses on mitochondrial genome data, including molecular sequences, RNA structures, and genetic maps.
  • The database incorporates taxonomic information for all represented eukaryotic species.
  • The system supports sophisticated searching, interactive browsing, and data downloading.

Conclusions:

  • GOBASE provides a fully operational and publicly accessible platform for organelle genomics research.
  • The database design supports complex queries, particularly in a comparative genomics context.
  • GOBASE enhances the accessibility and usability of organelle genetic data for the scientific community.