Database on the structure of large ribosomal subunit RNA

Area of Science:

• Molecular Biology
• Bioinformatics
• Genomics

Background:

• Ribosomal RNA (rRNA) is crucial for protein synthesis and cellular function.
• Access to curated and aligned rRNA sequence data is essential for comparative and evolutionary studies.
• Existing databases may lack comprehensive secondary structure information or user-friendly access.

Purpose of the Study:

• To present the updated rRNA WWW Server as a valuable resource for accessing large subunit rRNA sequences.
• To provide aligned sequences with integrated secondary structure information.
• To facilitate data retrieval and searching of associated metadata.

Main Methods:

• Compilation and alignment of 496 large subunit rRNA sequences.
• Integration of secondary structure information into the sequence database.
• Development of a web-accessible server with search functionalities.
• Provision of data download via anonymous FTP.

Main Results:

• The rRNA WWW Server now hosts 496 aligned large subunit rRNA sequences.
• Each sequence incorporates detailed secondary structure information.
• Searchable metadata includes literature references, accession numbers, and taxonomic data.
• Data is available in multiple formats for diverse research needs.

Conclusions:

• The rRNA WWW Server is a comprehensive and accessible resource for large subunit rRNA data.
• The integrated secondary structure information enhances the utility for structural and functional analyses.
• This database supports research in molecular evolution, phylogenetics, and ribosome function.