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IMGT, the International ImMunoGeneTics database

M P Lefranc1, V Giudicelli, C Busin

  • 1Laboratoire d'ImmunoGénétique Moléculaire, LIGM, UMR 5535 (CNRS, Université Montpellier II), 1919 route de Mende, 34293 Montpellier Cedex 5, France. lefranc.ligm.crbm.cnrs-mop.fr

Nucleic Acids Research
|February 21, 1998
PubMed
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The IMGT database provides integrated genetic information for Immunoglobulins (Ig), T cell Receptors (TcR), and Major Histocompatibility Complex (MHC) across vertebrate species. It offers expertly annotated sequences and alignment tables for research in immunology and evolution.

Area of Science:

  • Immunoinformatics
  • Genomics
  • Bioinformatics

Background:

  • The IMGT (international ImMunoGeneTics) database is a specialized resource for immunogenetic data.
  • It focuses on Immunoglobulins (Ig), T cell Receptors (TcR), and Major Histocompatibility Complex (MHC) across vertebrate species.

Purpose of the Study:

  • To establish a centralized, user-friendly data access point for all immunogenetics information.
  • To provide expertly annotated sequences, alignment tables, and tools for analyzing Ig, TcR, and MHC molecules.

Main Methods:

  • Integration of data from multiple sources into specialized databases (LIGM-DB, MHC/HLA-DB).
  • Expert annotation of nucleotide and protein sequences.
  • Development of tools like DNAPLOT for sequence alignment analysis.

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Main Results:

  • LIGM-DB contains over 23,000 Ig and TcR sequences from 78 species.
  • MHC/HLA-DB provides alignment tables for Class I and Class II Human Leukocyte Antigen.
  • IMGT collaborates with EMBL for comprehensive data coverage.

Conclusions:

  • IMGT serves as a crucial resource for immunogenetics research, facilitating studies in autoimmune diseases, AIDS, and cancer.
  • It supports advancements in therapeutic approaches like antibody engineering and understanding genome diversity.
  • The database is freely accessible, promoting widespread use in medical research and evolutionary studies.