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Current status of the SWISS-2DPAGE database
C Hoogland1, J C Sanchez, L Tonella
1Laboratoire d'Imagerie Moléculaire et Bioinformatique, Division d'Informatique Médicale, Hôpital Cantonal Universitaire, 24, rue Micheli-du-Crest, CH-1211 Genève 14, Switzerland. christine.hoogland@dim.hcuge.ch
Nucleic Acids Research
|February 21, 1998
Summary
The SWISS-2DPAGE database offers 2D gel electrophoresis images and protein details for human and microbial samples. It aids in protein identification and analysis using comprehensive reference maps.
Area of Science:
- Proteomics
- Bioinformatics
- Molecular Biology
Background:
- Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) is a key technique for protein separation and analysis.
- Databases are essential for organizing and accessing complex biological data, including protein information.
Purpose of the Study:
- To present the SWISS-2DPAGE database, a resource for 2D gel electrophoresis data.
- To provide access to identified protein information from various biological samples.
Main Methods:
- Compilation of 2D-PAGE images from human, Saccharomyces cerevisiae, Escherichia coli, and Dictyostelium discoideum.
- Integration of textual descriptions for identified proteins.
- Inclusion of virtual entries for SWISS-PROT sequences.
Main Results:
- The database contains 15 reference maps.
- Features 2088 identified spots corresponding to 410 distinct protein entries.
- Includes virtual entries for all SWISS-PROT sequences.
Conclusions:
- SWISS-2DPAGE serves as a valuable resource for researchers in proteomics and related fields.
- Facilitates protein identification and comparative analysis across different organisms.