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REBASE - restriction enzymes and methylases

R J Roberts1, D Macelis

  • 1New England BioLabs, 32 Tozer Road, Beverly, MA 01915, USA. roberts@neb.com

Nucleic Acids Research
|February 21, 1998
PubMed
Summary

REBASE is a comprehensive database for restriction enzymes and methylases, offering detailed information on recognition sites, cleavage sites, and commercial availability. It also lists homing endonucleases and provides access via web, FTP, and email.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Bioinformatics

Background:

  • Restriction enzymes and methylases are crucial tools in molecular biology.
  • Accurate and accessible information on these enzymes is vital for researchers.
  • Existing databases may lack comprehensive or up-to-date details.

Purpose of the Study:

  • To provide a centralized, comprehensive database for restriction enzymes and methylases.
  • To include information on recognition sites, cleavage sites, and commercial availability.
  • To also list homing endonucleases and facilitate data access.

Main Methods:

  • Data compilation from scientific literature and commercial sources.
  • Organization of information into a structured database.
  • Development of web-based and file transfer access methods.

Main Results:

  • REBASE database established with extensive information on restriction enzymes and methylases.
  • Includes recognition/cleavage sites, commercial availability, and homing endonucleases.
  • Data accessible via monthly email, anonymous FTP, and a dedicated website.

Conclusions:

  • REBASE serves as a vital resource for researchers in molecular biology and related fields.
  • The database enhances accessibility to critical enzymatic information.
  • Continuous updates ensure the relevance and utility of the REBASE resource.

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