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The ribonuclease P database

J W Brown1

  • 1Department of Microbiology, North Carolina State University, Raleigh, NC 27695, USA. jwbrown@mbio.ncsu.edu

Nucleic Acids Research
|February 21, 1998
PubMed
Summary
This summary is machine-generated.

Ribonuclease P (RNase P) is crucial for tRNA maturation. In bacteria, the RNA component of RNase P acts as a ribozyme, demonstrating catalytic activity independently.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Ribonuclease P (RNase P) is an essential enzyme responsible for the 5' maturation of transfer RNA (tRNA) precursors.
  • RNase P is a ribonucleoprotein complex with critical roles in RNA processing.
  • In bacterial systems, the RNA subunit of RNase P exhibits catalytic activity, classifying it as a ribozyme.

Purpose of the Study:

  • To provide a comprehensive compilation of Ribonuclease P (RNase P) related data.
  • To make sequence data, alignments, structural information, and models accessible to the scientific community.
  • To facilitate research on the structure and function of RNase P.

Main Methods:

  • Data collection and curation of Ribonuclease P (RNase P) sequences.
  • Generation of sequence alignments for comparative analysis.

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  • Development of secondary structure models and 3D models.
  • Establishment of a web-accessible database.

    • Main Results:

    • A centralized repository of Ribonuclease P (RNase P) sequences and associated data has been established.
    • The database includes sequence alignments, secondary structures, and three-dimensional models.
    • Access to this curated information is available via the World Wide Web.

    Conclusions:

    • The Ribonuclease P Database serves as a valuable resource for researchers studying tRNA biogenesis and ribozymes.
    • Accessibility of RNase P data promotes further investigation into its catalytic mechanism and biological significance.
    • The database supports comparative genomics and structural biology studies of RNase P.