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Oxidative stress and lung function

H J Schünemann1, P Muti, J L Freudenheim

  • 1Department of Social and Preventive Medicine, State University of New York at Buffalo 14214-3000, USA.

American Journal of Epidemiology
|December 24, 1997
PubMed
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Increased lipid peroxidation, indicated by plasma thiobarbituric acid-reactive substances (p-TBARS), is linked to reduced lung function (FEV1%) in adults. Lower antioxidant levels, like serum bilirubin, also correlate with poorer lung function, suggesting oxidative stress impacts pulmonary health.

Area of Science:

  • Pulmonary Medicine
  • Oxidative Stress Research
  • Biochemistry

Background:

  • Lung function can be influenced by oxidative stress and antioxidant status.
  • Limited data exists on the direct relationship between blood oxidant/antioxidant levels and lung function.

Purpose of the Study:

  • To investigate the association between markers of lipid peroxidation and antioxidant compounds with lung function (FEV1%) in a general adult population.
  • To explore the role of oxidative stress in pulmonary airway narrowing.

Main Methods:

  • Cross-sectional study of 132 non-smoking adults (aged 37-73) in New York.
  • Measured lung function (FEV1%) and blood levels of lipid peroxidation markers (p-TBARS, LDL/VLDL cholesterol-TBARS) and antioxidants (glutathione, glutathione peroxidase, TEAC, bilirubin).

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Main Results:

  • FEV1% showed a significant negative association with p-TBARS (r = -0.19).
  • Borderline significant negative associations were found between FEV1% and LDL/VLDL cholesterol-TBARS (r = -0.16) and glutathione (r = -0.16).
  • FEV1% had a positive association with serum bilirubin (r = 0.15). Participants with the lowest FEV1% had higher p-TBARS and lower bilirubin levels.

Conclusions:

  • Increased lipid peroxidation is associated with pulmonary airway narrowing in the general population.
  • Oxidative stress markers may play a role in reduced lung function.