Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain cavernoma: a dynamic lesion

J P Houtteville1

  • 1Department of Neurosurgery, C.H.U. Caen, France.

Surgical Neurology
|December 24, 1997
PubMed
Summary
This summary is machine-generated.

Brain cavernomas can be dynamic due to bleeding and intrinsic growth. Surgical removal is recommended for symptomatic cases to prevent disability or death.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mutations within the MGC4607 gene cause cerebral cavernous malformations.

American journal of human genetics·2004
Same author

[Cerebellar, pulmonary and cutaneous localizations of juvenile xanthogranuloma].

Annales de dermatologie et de venereologie·2002
Same author

Prospective follow-up of 33 asymptomatic patients with familial cerebral cavernous malformations.

Neurology·2001
Same author

Pediatric cerebral aneurysms.

Journal of neurosurgery·2001
Same author

Non-invasive grading of oligodendrogliomas: correlation between in vivo metabolic pattern and histopathology.

European journal of nuclear medicine·2000
Same author

The natural history of familial cerebral cavernomas: a retrospective MRI study of 40 patients.

Neuroradiology·2000
Same journal

Commentary.

Surgical neurology·2010
Same journal

Implant design may influence delayed heterotopic ossification after total disk arthroplasty in lumbar spine.

Surgical neurology·2010
Same journal

Addendum to "In this issue...".

Surgical neurology·2010
Same journal

Anterior interosseous syndrome vs flexor pollicis longus tendon rupture: electrodiagnosis or sonography?

Surgical neurology·2010
Same journal

Transcranial/transnasal approach for nonpituitary sellar lesions.

Surgical neurology·2010
Same journal

What will you do with the rest of your life?

Surgical neurology·2010
See all related articles

Area of Science:

  • Neuroscience
  • Vascular Neurology
  • Neurosurgery

Background:

  • Brain cavernomas (cerebral cavernous malformations) have a high prevalence (0.50%) but often lack aggressive clinical behavior.
  • Understanding the factors contributing to cavernoma dynamism is crucial for patient management.

Observation:

  • Hemorrhage is the most frequent phenomenon, often from peripheral cavern rupture.
  • Calcifications are associated with chronic epilepsy, and while bleeding risk is low, it influences surgical decisions.
  • Intrinsic growth of the cavernous matrix, potentially driven by angiogenic factors, and de novo lesion appearance were observed.

Findings:

  • Extralesional hemorrhages tend to resorb but carry recurrence risk, especially in the brainstem.
  • Intralesional bleeding can form cysts; chronic effusions may cause perilesional atrophy, disturbing brain metabolism.

Related Experiment Videos

  • Cavernoma dynamism is influenced by extrinsic factors (hemorrhage) and intrinsic factors (matrix growth).

    • Implications:

    • Symptomatic cavernomas require total surgical removal to mitigate risks of disability and mortality.
    • Further research into angiogenic factors may elucidate cavernoma growth mechanisms.
    • Long-term monitoring is essential for patients with cavernomas, particularly those with risk factors like brainstem location or calcification.