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[Lymphoplasmacellular osteomyelitis]

R Krauspe1, H Girschick, H I Huppertz

  • 1Orthopädische Klinik, König-Ludwig-Haus, Julius-Maximilians-Universität Würzburg.

Der Orthopade
|December 24, 1997
PubMed
Summary
This summary is machine-generated.

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Chronic lymphoplasmacellular osteomyelitis, a rare condition, typically presents with pain and swelling, not fever. Definitive diagnosis requires integrating clinical, radiological, and histological findings with negative cultures.

Area of Science:

  • Orthopedics
  • Rheumatology
  • Pathology

Context:

  • Chronic lymphoplasmacellular osteomyelitis is a rare bone infection affecting children, adolescents, and adults.
  • It is characterized by a chronic course with periods of symptoms and remission, distinct from acute osteomyelitis.
  • The condition is often associated with dermatological conditions and synovitis, leading to the SAPHO syndrome.

Purpose:

  • To detail the clinical presentation, diagnostic criteria, and management of chronic lymphoplasmacellular osteomyelitis.
  • To differentiate this condition from bacterial osteomyelitis and other bone pathologies.
  • To highlight the diagnostic challenges and the importance of a multidisciplinary approach.

Summary:

  • This condition typically presents with pain and swelling, commonly affecting the clavicle and long bones in younger individuals, and clavicles/ribs in adults.

Related Experiment Videos

  • Diagnostic hallmarks include non-specific laboratory findings, characteristic radiological changes (osteolytic/sclerotic lesions, periosteal reactions), and specific histological patterns (lymphocytic/plasma-cellular infiltrates).
  • Negative bacteriological cultures are crucial for diagnosis, alongside a comprehensive evaluation of clinical, radiological, and histological data. The SAPHO syndrome encompasses synovitis, acne, pustulosis, hyperostosis, and osteomyelitis.

    • Impact:

    • Nonsteroidal anti-inflammatory drugs are effective for symptom management, while antibiotics and major surgery are generally not recommended.
    • The prognosis for growth and function is excellent long-term, despite potential recurrences.
    • Understanding the distinct features of chronic lymphoplasmacellular osteomyelitis aids in accurate diagnosis and appropriate management, preventing unnecessary interventions.