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Related Experiment Videos

First-trimester invasive procedures and congenital abnormalities

A Greenough1, S Naik, B Yuksel

  • 1Department of Child Health, King's College Hospital, London, UK.

Acta Paediatrica (Oslo, Norway : 1992)
|December 24, 1997
PubMed
Summary
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First-trimester amniocentesis (EA) and chorion villus sampling (CVS) are linked to more congenital anomalies in infants. These invasive procedures show a higher incidence of birth defects compared to no invasive procedures.

Area of Science:

  • Obstetrics and Gynecology
  • Fetal Medicine
  • Pediatric Health

Background:

  • First-trimester invasive prenatal procedures like amniocentesis (EA) and chorion villus sampling (CVS) are commonly used for genetic testing.
  • The potential association between these procedures and congenital anomalies requires thorough investigation to ensure fetal safety.

Purpose of the Study:

  • To prospectively evaluate whether first-trimester amniocentesis (EA) or chorion villus sampling (CVS) increases the incidence of congenital anomalies.
  • To compare the rates of congenital anomalies in infants whose mothers underwent EA, CVS, or no invasive antenatal procedures.

Main Methods:

  • A prospective study involving three groups: first-trimester amniocentesis (EA, n=352), chorion villus sampling (CVS, n=348), and a control group with no invasive procedures (n=264).

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  • Infants were examined at a median age of 5 months to assess for congenital anomalies.
  • Statistical analysis was performed to compare anomaly rates between groups.

    • Main Results:

    • Both EA and CVS groups exhibited a significantly higher proportion of infants with congenital anomalies (18/352 and 22/348, respectively) compared to the control group (4/264) (p < 0.01).
    • Compression abnormalities were more frequent in the EA group than controls (p < 0.05), but not in the CVS group.
    • Minor isolated limb abnormalities affecting digits were observed in both EA (3/352) and CVS (6/348) groups.

    Conclusions:

    • First-trimester invasive procedures, including amniocentesis and chorion villus sampling, are associated with an increased risk of congenital anomalies.
    • Specific types of anomalies, such as compression abnormalities, may be more prevalent following EA.
    • While some limb abnormalities were minor, their occurrence warrants consideration when counseling patients regarding invasive procedures.