Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exhausted subjects, exhausted systems

A Appels1

  • 1Department of Medical Psychology, University of Maastricht, The Netherlands.

Acta Physiologica Scandinavica. Supplementum
|January 1, 1997
PubMed
Summary

Vital exhaustion, a state of extreme tiredness, irritability, and demoralization, can precede myocardial infarction and increase coronary event risk post-angioplasty. This condition may stem from reduced hypothalamic-pituitary-adrenal axis activity due to prolonged stress and inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postnatal corticosteroid response in neonates < 32 weeks and relation with placental pathology.

European journal of pediatrics·2022
Same author

Vital exhaustion as a risk factor of myocardial infarction: a case-control study in Venezuela.

International journal of behavioral medicine·2005
Same author

Assessment of vital exhaustion and identification of subjects at increased risk of myocardial infarction in general practice.

Psychosomatics·2004
Same author

Unique female indicators of coronary heart disease: do they exist?

Circulation·2004
Same author

Vital exhaustion as a risk indicator for first stroke.

Psychosomatics·2004
Same author

The nature of the depressive symptomatology preceding myocardial infarction.

Behavioral medicine (Washington, D.C.)·2001

Area of Science:

  • Cardiology
  • Psychoneuroimmunology
  • Stress Physiology

Background:

  • Vital exhaustion, marked by fatigue, irritability, and demoralization, is linked to adverse cardiovascular outcomes.
  • This psychological state may precede myocardial infarction (MI) and complicate recovery after procedures like angioplasty.

Purpose of the Study:

  • To explore the potential link between vital exhaustion and cardiovascular events.
  • To investigate the physiological underpinnings of vital exhaustion in the context of cardiovascular disease.

Main Methods:

  • The study reviews existing literature on vital exhaustion and its association with cardiovascular events.
  • It posits a physiological mechanism involving the hypothalamic-pituitary-adrenal (HPA) axis.

Main Results:

  • Vital exhaustion is identified as a precursor to myocardial infarction.
  • It is also associated with an increased risk of recurrent coronary events following angioplasty.

Conclusions:

  • Vital exhaustion may serve as a significant risk factor for cardiovascular events.
  • The state likely reflects a dysregulated homeostatic response to chronic stress and inflammation, possibly involving decreased HPA axis activity.

Related Experiment Videos