Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Traumatic stress and attachment

S Wang1

  • 1Department of Psychiatry, Yale University School of Medicine, West Haven, CT, USA.

Acta Physiologica Scandinavica. Supplementum
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel G protein-coupled P2 purinoceptor (P2Y3) activated preferentially by nucleoside diphosphates.

Molecular pharmacology·1996
Same author

Endometrial lymphomyeloid cells in abnormal uterine bleeding due to levonorgestrel (Norplant).

Human reproduction (Oxford, England)·1996
Same author

Hydrophobicity and sorption of chlorophenolates to lipid membranes.

Chemosphere·1996
Same author

Inhibition of lipid peroxidation in low-density lipoprotein by the flavonoid myrigalone B and ascorbic acid.

Biochemical pharmacology·1996
Same author

The fourth EF-hand of calmodulin and its helix-loop-helix components: impact on calcium binding and enzyme activation.

Biochemistry·1996
Same author

Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

Journal of medicinal chemistry·1996
Same journal

Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle.

Acta physiologica Scandinavica. Supplementum·2002
Same journal

Muscle reflex and central motor control of neuroendocrine activity, glucose homeostasis and circulation during exercise.

Acta physiologica Scandinavica. Supplementum·2001
Same journal

Biology of Nitric Oxide, 6th International Meeting. Stockholm, Sweden, September 5-8, 1999. Abstracts.

Acta physiologica Scandinavica. Supplementum·2000
Same journal

Adaptation of human skeletal muscle to training and anabolic steroids.

Acta physiologica Scandinavica. Supplementum·2000
Same journal

On the role of PGD2 metabolites as markers of mast cell activation in asthma.

Acta physiologica Scandinavica. Supplementum·1999
Same journal

Symposium on ion motive ATPases. Introduction.

Acta physiologica Scandinavica. Supplementum·1999
See all related articles

Traumatic stress disrupts hormonal balance, affecting self-preservation and attachment behaviors. Chronic stress can lead to dissociation between the sympatho-adrenal system and the hypothalamic-pituitary-adrenal (HPA) axis.

Area of Science:

  • Neuroendocrinology
  • Stress Physiology
  • Behavioral Neuroscience

Background:

  • Traumatic stress activates the sympatho-adrenal system, thyroid system, and hypothalamic-pituitary-adrenal (HPA) axis, increasing stress hormones like noradrenaline, adrenaline, and cortisol.
  • Chronic stress in animals and humans with posttraumatic stress disorder (PTSD) can cause dissociation between the sympatho-adrenal medullary and HPA systems.
  • Self-preservative behaviors (power, control) are linked to catecholamines, thyroid hormones, and left hemispheric function, while species-preservative behaviors (attachment, familiarity) are linked to cortisol, oxytocin, and right hemispheric function.

Purpose of the Study:

  • To explore the neuroendocrine and hemispheric changes associated with traumatic stress.
  • To investigate the dissociation between the sympatho-adrenal system and HPA axis in chronic stress.
  • To examine the impact of traumatic stress on self-preservative and species-preservative behaviors.

Related Experiment Videos

Main Methods:

  • Review of existing literature on traumatic stress, neuroendocrine responses, and hemispheric functioning.
  • Analysis of studies involving animal models and human subjects with PTSD.
  • Integration of findings related to catecholamines, cortisol, thyroid hormones, oxytocin, and brain lateralization.

Main Results:

  • Acute stress leads to a general activation of stress response systems.
  • Chronic stress can result in a dissociation, with sustained sympatho-adrenal activation but suppressed HPA axis responsivity.
  • Traumatic stress appears to disrupt hemispheric balance, potentially leading to suppressed cortisol and impaired attachment behaviors.

Conclusions:

  • Traumatic stress significantly alters neuroendocrine function and hemispheric balance.
  • The dissociation between stress systems and the shift in hemispheric dominance may underlie behavioral changes observed in chronic stress and PTSD.
  • Understanding these mechanisms is crucial for developing targeted interventions for stress-related disorders.