The role of ethanol availability on stress-induced increases in ethanol consumption

Exposure to stressors can increase ethanol consumption and ethanol can attenuate the behavioral and biochemical effects of stressors. This study determined whether the availability of ethanol during the period of exposure to repeated restraint alters the poststress increase in ethanol intake. Seven days of restraint increased ethanol intake on the first poststress test only in animals deprived of ethanol during the restraint period. These results indicate that the availability of ethanol during exposure to restraint can attenuate the impact of restraint on ethanol intake. Ethanol intake was also positively related to novelty-induced locomotion and restraint eliminated this relationship. However, amphetamine-induced locomotion was not altered by either restraint or EtOH intake. These results indicate that voluntary ethanol intake can attenuate the impact of restraint stress and that restraint stress can alter the influence of ethanol on novelty-induced locomotion. It is suggested that this symmetrical relationship between ethanol intake and restraint stress may be involved in an interactive manner that determines stress-induced ethanol consumption.