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Related Experiment Videos

Metoclopramide plasma concentration in neonates

F Vauzelle-Kervroedan1, E Rey, P D'Athis

  • 1Service de Pharmacologie Perinatale et Pédiatrique, Université René Descartes Paris V, France.

International Journal of Clinical Pharmacology and Therapeutics
|December 24, 1997
PubMed
Summary

Metoclopramide (M) plasma concentrations in neonates were similar before and after dosing. Lower gestational and postconceptional ages correlated with lower M plasma levels, suggesting dosage adjustments are needed.

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Area of Science:

  • Neonatal Pharmacology
  • Clinical Pharmacy
  • Drug Metabolism

Background:

  • Metoclopramide is frequently used in neonates.
  • Understanding metoclopramide pharmacokinetics in neonates is crucial for safe and effective treatment.

Purpose of the Study:

  • To assess metoclopramide (M) plasma concentrations at steady-state in neonates.
  • To investigate the relationship between metoclopramide plasma levels and neonatal age.

Main Methods:

  • Multiple-dose oral metoclopramide treatment in 5 neonates (3 premature, 2 term).
  • Measurement of metoclopramide plasma concentrations (Cmin and C1h) at steady-state.
  • Correlation analysis between plasma concentrations and gestational/postconceptional age.

Main Results:

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  • Mean Cmin (91.6 ng/ml) was not significantly different from C1h (87.4 ng/ml).
  • A significant negative correlation was observed between Cmin and both gestational age and postconceptional age.

Conclusions:

  • Neonatal metoclopramide dosage may require adjustment based on gestational and postconceptional age.
  • Lower ages necessitate lower metoclopramide doses to avoid potential toxicity.