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Metoclopramide plasma concentration in neonates
F Vauzelle-Kervroedan1, E Rey, P D'Athis
1Service de Pharmacologie Perinatale et Pédiatrique, Université René Descartes Paris V, France.
International Journal of Clinical Pharmacology and Therapeutics
|December 24, 1997
Summary
Metoclopramide (M) plasma concentrations in neonates were similar before and after dosing. Lower gestational and postconceptional ages correlated with lower M plasma levels, suggesting dosage adjustments are needed.
Area of Science:
- Neonatal Pharmacology
- Clinical Pharmacy
- Drug Metabolism
Background:
- Metoclopramide is frequently used in neonates.
- Understanding metoclopramide pharmacokinetics in neonates is crucial for safe and effective treatment.
Purpose of the Study:
- To assess metoclopramide (M) plasma concentrations at steady-state in neonates.
- To investigate the relationship between metoclopramide plasma levels and neonatal age.
Main Methods:
- Multiple-dose oral metoclopramide treatment in 5 neonates (3 premature, 2 term).
- Measurement of metoclopramide plasma concentrations (Cmin and C1h) at steady-state.
- Correlation analysis between plasma concentrations and gestational/postconceptional age.
Main Results:
- Mean Cmin (91.6 ng/ml) was not significantly different from C1h (87.4 ng/ml).
- A significant negative correlation was observed between Cmin and both gestational age and postconceptional age.
Conclusions:
- Neonatal metoclopramide dosage may require adjustment based on gestational and postconceptional age.
- Lower ages necessitate lower metoclopramide doses to avoid potential toxicity.