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A new route, jet injection for anesthetic induction in children--III. Ketamine pharmacokinetic studies
E F Domino1, E K Zsigmond, V Kovacs
1Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109-0632, USA.
Abstract:
The jet injector route for ketamine was used on 30 children 1-6 years of age undergoing various surgical procedures. A randomly selected dose of 2.5, 3.5, or 6.0 mg/kg of ketamine was given to induce anesthesia. Peak plasma ketamine levels did not follow a simple arithmetic increment related to dose. Dosage based on mg/m2 body surface area or mg/kg body weight provided similar blood levels of ketamine. The beta-phase t1/2 of ketamine in these children was shorter than that found in adults. Considerable individual variability was observed in both the plasma levels to a given dose of jet-injected ketamine and in the beta-phase t1/2. The ketamine beta-t1/2s were not dose related.
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