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Studies on urolithiasis in Israel

J L Zaidman, N Pinto

    The Journal of Urology
    |June 1, 1976
    PubMed
    Summary

    Kidney stone composition analysis in Israel revealed distinct ethnic variations in calcium oxalate, calcium phosphate, and uric acid stones. Uric acid stones were more prevalent in specific Jewish and Middle Eastern groups.

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    Area of Science:

    • Nephrology and Urology
    • Geographic Epidemiology of Kidney Stones

    Background:

    • Kidney stones (urinary calculi) represent a significant health concern.
    • Understanding the composition and incidence of kidney stones is crucial for public health initiatives.
    • Ethnic and geographic factors may influence the prevalence of different stone types.

    Purpose of the Study:

    • To analyze the chemical composition of kidney stones in a specific region of Israel.
    • To determine the relative incidence of different urinary calculi types across various ethnic groups and age demographics.
    • To investigate potential correlations between ethnicity, geographic origin, and kidney stone composition.

    Main Methods:

    • Chemical analysis was employed to determine the composition of 1,000 kidney stones.
    • Urinary calculi incidence was assessed in 500 patients representing diverse ages and ethnic backgrounds.
    • Data were collected on patient ethnicity, geographic origin, and age at the onset of urolithiasis.

    Main Results:

    • The predominant kidney stone types were calcium oxalate, calcium phosphate, and uric acid.
    • Calcium oxalate and calcium phosphate stones were less common in Israeli-born Jews compared to other ethnic groups (44% vs. 54-64%).
    • Uric acid stones showed a 2-3 times higher incidence in Israeli-born Jews, Lebanese, Iranians, Iraqis, Syrians, and Ashkenazim (16-29%) than in other groups.
    • Urolithiasis onset occurred after age 20 in over 60% of patients.
    • Significantly younger age at onset was observed in Israeli-born Jews (25.7%), North Africans (13.8%), and Arabs (18%).

    Conclusions:

    • Significant ethnic and geographic variations exist in kidney stone composition within Israel.
    • Specific ethnic groups exhibit a higher predisposition to certain types of urinary calculi, notably uric acid stones.
    • Early onset of urolithiasis is noted in specific populations, suggesting potential genetic or environmental influences requiring further investigation.

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