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Reengineering a type II beta-turn as a potential helix nucleator. Part I. Crystal structure of
F Fabiola1, V Pattabhi, E B Raju
1Department of Biophysics, University of Madras, India.
Abstract:
The crystal structure of Boc-Val1-Pro2-(D)Asp3-Asp4-Val5-OMe is described as a type II beta-turn reengineered into a potential helix nucleator. (D)Asp3 in the peptide is responsible for the configurationally guided LD chiral type II beta-turn centered at Pro2-(D)Asp3, as well as the partially developed LL chiral type I beta-turn centered at Asp4-Val5 by acceptance of a conformation nucleating H-bond from Val5NH to its carboxylic oxygen.