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Sibling uropathology

J Y Dwoskin

    The Journal of Urology
    |June 1, 1976
    PubMed
    Summary

    Many siblings of individuals with urinary tract issues remain undiagnosed. Nearly half of asymptomatic siblings showed uropathology, with reflux common in families affected by this condition.

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    Area of Science:

    • Pediatric Nephrology
    • Urology
    • Genetics

    Background:

    • Uropathology, including vesicoureteral reflux (VUR), can have a familial component.
    • Undiagnosed uropathology in siblings may lead to delayed diagnosis and treatment.

    Purpose of the Study:

    • To investigate the prevalence of undiagnosed uropathology in siblings of patients with known urinary tract abnormalities.
    • To determine the association between proband diagnosis and sibling uropathology.

    Main Methods:

    • Evaluation of 197 sibships.
    • Assessment of sibling uropathology, specifically reflux and other abnormalities, in relation to the proband's diagnosis.

    Main Results:

    • 47.6% of evaluated siblings (excluding probands) had undiagnosed uropathology.
    • When the proband had reflux, 26.5% of asymptomatic siblings also had reflux.
    • If the proband had other uropathologies, 13.2% of siblings had reflux and 46% had other abnormalities.

    Conclusions:

    • A significant proportion of siblings of patients with uropathology remain undiagnosed.
    • Reflux and other urinary tract abnormalities show familial clustering, suggesting a genetic or shared environmental influence.

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