Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosomal aberrations in Wilms' tumour

C M Kullendorff1, T Wiebe

  • 1Department of Paediatric Surgery, University Hospital, Lund, Sweden.

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|December 24, 1997
PubMed
Summary

Genetic analysis of Wilms' tumour revealed acquired chromosome aberrations in 13 patients. Numerical changes were common, highlighting the complexity of genetic alterations in this pediatric cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Moderate dose cranial radiotherapy causes central adrenal insufficiency in long-term survivors of childhood leukaemia.

Pituitary·2013
Same author

Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. Results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol.

Annals of oncology : official journal of the European Society for Medical Oncology·2010
Same author

Returning to a changed ordinary life--families' lived experience after completing a child's cancer treatment.

European journal of cancer care·2010
Same author

High risk of azoospermia in men treated for childhood cancer.

International journal of andrology·2010
Same author

Chemotherapy in Ewing's sarcoma. The Scandinavian Sarcoma Group experience.

Acta orthopaedica Scandinavica. Supplementum·2004
Same author

Chemotherapy in osteosarcoma. The Scandinavian Sarcoma Group experience.

Acta orthopaedica Scandinavica. Supplementum·2004

Area of Science:

  • Oncology
  • Genetics
  • Pediatric Medicine

Background:

  • Wilms' tumour is a common pediatric kidney cancer.
  • Understanding the genetic basis of Wilms' tumour is crucial for diagnosis and treatment.
  • Previous studies have identified various genetic alterations, but heterogeneity remains a challenge.

Purpose of the Study:

  • To genetically analyze tumor samples from patients with Wilms' tumour.
  • To identify and characterize acquired chromosomal aberrations in Wilms' tumour.
  • To explore the cytogenetic heterogeneity and its implications for tumor development.

Main Methods:

  • Genetic analysis of tumor samples from 26 consecutive Wilms' tumour patients.
  • Karyotyping to detect numerical and structural chromosomal aberrations.

Related Experiment Videos

  • Analysis of constitutional chromosomal changes.

    • Main Results:

    • Clonal acquired chromosome aberrations were identified in 13 out of 26 patients.
    • Numerical chromosome changes were observed in 13 patients, with 16 patients showing numerical alterations.
    • Breakpoint of chromosome 1 was found in 6 patients; no structural alterations of chromosome 11 were detected.
    • One patient presented with trisomy 18 as the sole constitutional change.

    Conclusions:

    • Significant cytogenetic heterogeneity exists in Wilms' tumour.
    • Acquired chromosomal aberrations are common in Wilms' tumour.
    • Further correlation with histology and clinical course is needed to understand the phenotypic impact of these aberrations.