Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Primary motor cortex reorganization in a long-term monkey amputee

M H Schieber1, R K Deuel

  • 1Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA. mhs@cvs.rochester.edu

Somatosensory & Motor Research
|January 1, 1997
PubMed
Summary

The primary motor cortex (M1) shows limited reorganization after upper extremity amputation. Motor maps suggest unmasking of shoulder representations rather than extensive cortical invasion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Coherency between Spike and LFP Activity in M1 during Hand Movements.

International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering·2025
Same author

Decoding M1 neurons during multiple finger movements.

Journal of neurophysiology·2007
Same author

Constraints on somatotopic organization in the primary motor cortex.

Journal of neurophysiology·2001
Same author

Orderly somatotopy in primary motor cortex: does it exist?

NeuroImage·2001
Same author

Language regression in childhood.

Pediatric neurology·2001
Same author

Tension distribution to the five digits of the hand by neuromuscular compartments in the macaque flexor digitorum profundus.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

Area of Science:

  • Neuroscience
  • Neuroplasticity
  • Motor Cortex Research

Background:

  • The adult brain exhibits plasticity, but the extent of reorganization in the primary motor cortex (M1) following early-onset limb loss remains incompletely understood.
  • Investigating M1's response to amputation is crucial for understanding sensorimotor control and potential therapeutic targets.

Purpose of the Study:

  • To map the primary motor cortex (M1) in a macaque with a long-standing upper extremity amputation.
  • To investigate the cortical reorganization and functional representation within M1 following early-onset deafferentation and de-efferentation.

Main Methods:

  • Intracortical microstimulation (ICMS) was used to map the M1 upper extremity region in a macaque with a right forelimb amputation since before age two.
  • Evoked movements from the shoulder girdle and stump were analyzed across the contralateral M1.

Related Experiment Videos

Main Results:

  • ICMS evoked shoulder girdle and stump movements throughout the left M1 upper extremity region.
  • The size of the amputated limb's M1 representation was comparable to the intact limb's, but required longer stimulus trains or higher currents at more loci.
  • These findings suggest potential unmasking of high-threshold shoulder representations or invasion by surrounding shoulder representations.

Conclusions:

  • M1 exhibits limited but specific reorganization in response to early-onset upper extremity amputation.
  • The observed changes in M1 may reflect unmasking of existing representations rather than extensive cortical map expansion.
  • Differences in M1 reorganization compared to S1 (somatosensory cortex) may highlight distinct cortical processing mechanisms for motor versus sensory functions.