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How rolling circle plasmids control their copy number
1CFSAN Divn of Microbiological Studies, US Food and Drug Administration, Washington, DC 20204, USA. axr@vm.cfsan.fda.gov
Trends in Microbiology
|December 24, 1997
Abstract:
Rolling circle DNA replication is inherently continuous and unregulated. This 'go-for-broke' strategy works well for lytic phages but is suicidal for plasmids that must coexist with their host. Plasmids have consequently evolved elaborate copy number control systems that operate at the transcriptional, translational and post-translational levels.