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Filamentous growth in budding yeast

¹Center for Molecular Oncology, University of Chicago, Chicago, IL 60637, USA. skron@midway.uchicago.edu

Trends in Microbiology

|December 24, 1997

Summary

Most laboratory yeast, Saccharomyces cerevisiae, can now grow filaments due to a single mutation. This genetic change explains why domesticated yeast differ from their wild ancestors, resolving the mystery of yeast dimorphism.

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Area of Science:

Microbiology
Genetics
Molecular Biology

Background:

Recent discovery of limited filamentous growth in laboratory Saccharomyces cerevisiae strains.
Previous lack of understanding regarding the nonfilamentous nature of most yeast strains.

Purpose of the Study:

To genetically analyze the dimorphism in Saccharomyces cerevisiae.
To understand the genetic basis for the difference between filamentous and nonfilamentous yeast strains.

Main Methods:

Genetic analysis of Saccharomyces cerevisiae strains.
Investigating the molecular basis of filamentous growth.

Main Results:

Identified a single point mutation responsible for filamentous growth.
This mutation has broad consequences, distinguishing domesticated yeast from wild ancestors.

Conclusions:

A single genetic alteration explains the dimorphic capability in laboratory yeast.
Resolved the puzzle of why most Saccharomyces cerevisiae strains are nonfilamentous.

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