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Amniotic membrane transplantation for conjunctival surface reconstruction

S C Tseng1, P Prabhasawat, S H Lee

  • 1Department of Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, USA. stseng@mednet.med.miami.edu

American Journal of Ophthalmology
|December 24, 1997
PubMed
Summary

Human amniotic membrane transplantation offers a viable option for conjunctival reconstruction after lesion removal or scar lysis. This method shows promise for successful surface repair, particularly when surrounding tissues are healthy.

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Conjunctival defects pose reconstructive challenges.
  • Large lesions and symblepharon require effective surgical and regenerative solutions.

Purpose of the Study:

  • To evaluate preserved human amniotic membrane for conjunctival defect reconstruction.
  • Assessing its efficacy after large lesion removal and symblepharon lysis.

Main Methods:

  • Amniotic membrane transplantation performed on 15 patients (16 eyes).
  • Procedures included removal of large conjunctival lesions, scars, or symblepharon.

Main Results:

  • Successful reconstruction achieved in 11 eyes over a mean follow-up of 10.9 months.

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  • Improved visual acuity and motility restriction resolution observed.
  • Partial success and complications like inflammation, scarring, and cyst formation were noted in some cases.

    • Conclusions:

    • Amniotic membrane transplantation is a potential alternative for conjunctival reconstruction.
    • It is particularly suitable for defects associated with tumors, scars, or symblepharon when adjacent conjunctiva is healthy.