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Treatment of fungal corneal ulcers with amphotericin B ointment
H Hirose1, H Terasaki, S Awaya
1Department of Ophthalmology, Nagoya University, School of Medicine, Japan. hirohiro@tsuru.med.nagoya-u.ac.jp
Purpose:
To report two patients with severe fungal corneal ulcers who were treated successfully with topical amphotericin B ointment.
Methods:
Two eyes of two patients developed corneal ulcers and hypopyon after corneal foreign body removal. Aspergillus fumigatus and Fusarium solani were isolated in Patients 1 and 2, respectively. By antifungal susceptibility testing, amphotericin B was shown to have the lowest minimal inhibitory concentration.
Result:
Topical administration of amphotericin B ointment resulted in dramatic improvement in fungal corneal ulcers.
Conclusions:
Antifungal susceptibility tests may aid with selection of antifungal agents. Amphotericin B ointment is one of the promising therapies for keratomycosis caused by antimycotic-resistant fungi.