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BE-32030 A, B, C, D and E, new antitumor substances produced by Nocardia sp. A32030
M Tsukamoto1, K Murooka, S Nakajima
1Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Tsukuba, Japan.
The Journal of Antibiotics
|December 24, 1997
Abstract:
New antitumor substances, designated BE-32030A, B, C, D and E, were isolated from the culture broth of Nocardia sp. A32030. The active principles were extracted from the mycelium by methanol and purified by Sephadex LH-20 and reversed-phase column chromatographies and finally by reversed-phase HPLC. BE-32030A, B, C, D and E inhibited the growth of P388 murine leukemia, DLD-1 human colon cancer, PC-13 human lung cancer and MKN-45 human stomach cancer cell lines.