Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A compact, versatile inhalation exposure chamber for small animal studies

M R Montgomery, R E Anderson, G A Mortenson

    Laboratory Animal Science
    |June 1, 1976
    PubMed
    Summary

    A novel inhalation exposure chamber allows continuous exposure of 6 small animals to corrosive gases like ozone. It features individual animal access, chronic exposure support, and a safety mechanism for exhaust failures.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Measuring living standards with proxy variables.

    Demography·2000
    Same author

    Who's afraid of Kety-Schmidt?

    The Annals of thoracic surgery·1995
    Same author

    Effect of intermittent reperfusion and nitric oxide synthase inhibition on infarct volume during reversible focal cerebral ischemia.

    Journal of neurosurgery·1995
    Same author

    Effects of intermittent reperfusion on brain pHi, rCBF, and NADH during rabbit focal cerebral ischemia.

    Stroke·1995
    Same author

    Detection of hydroxyl radicals upon interaction of ozone with aqueous media or extracellular surfactant: the role of trace iron.

    Archives of biochemistry and biophysics·1995
    Same author

    Treatment with basic fibroblastic growth factor following focal cerebral ischemia does not prevent neuronal injury.

    Journal of the neurological sciences·1995

    Area of Science:

    • Toxicology
    • Laboratory Animal Science
    • Environmental Health

    Background:

    • Standard laboratory setups often lack specialized equipment for controlled inhalation studies.
    • Exposure to corrosive atmospheres like ozone poses significant challenges for animal research.
    • Maintaining experimental integrity during chronic exposure requires careful chamber design.

    Purpose of the Study:

    • To design and describe a novel inhalation exposure chamber for small laboratory animals.
    • To enable continuous exposure to corrosive atmospheres within a standard laboratory exhaust hood.
    • To ensure animal welfare and experimental control during toxic gas exposure studies.

    Main Methods:

    • Construction of an inhalation chamber using non-corrosive materials.
    • Integration of a dual-chamber system for individual animal access without atmospheric disturbance.
    • Inclusion of facilities for ad libitum food and water provision for chronic studies.
    • Development of a safety mechanism to halt toxic gas generation upon exhaust system failure.

    Main Results:

    • The chamber successfully fits within a standard laboratory exhaust hood.
    • It accommodates continuous exposure for up to 6 small laboratory animals.
    • The design allows for individual animal access, maintaining the experimental atmosphere.
    • The chamber is easily disassembled for cleaning and includes a fail-safe mechanism.

    Conclusions:

    • The developed inhalation exposure chamber is a practical and safe tool for toxicological research involving corrosive gases.
    • Its design facilitates chronic exposure studies while ensuring animal welfare and experimental integrity.
    • The integrated safety feature enhances laboratory safety during hazardous gas experiments.

    Related Experiment Videos