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Ageing and calcium metabolism

R Bouillon1, G Carmeliet, S Boonen

  • 1Laboratory for Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Belgium.

Bailliere'S Clinical Endocrinology and Metabolism
|July 1, 1997
PubMed
Summary

Ageing impairs calcium and vitamin D metabolism, potentially leading to secondary hyperparathyroidism and bone loss. Optimizing calcium intake and maintaining vitamin D levels are crucial for preventing age-related osteoporosis.

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Area of Science:

  • Gerontology
  • Metabolic Medicine
  • Nutritional Science

Background:

  • Aging significantly impacts calcium and vitamin D metabolism.
  • Reduced intake, sunlight exposure, and impaired vitamin D production/absorption are common in the elderly.
  • These metabolic changes can lead to secondary hyperparathyroidism and accelerated bone loss.

Purpose of the Study:

  • To investigate the alterations in calcium and vitamin D metabolism during aging.
  • To understand the role of these alterations in the pathogenesis of senile osteoporosis.
  • To identify preventive strategies for age-related bone loss.

Main Methods:

  • The study reviews existing literature on calcium and vitamin D metabolism in aging.
  • It analyzes the consequences of altered metabolism, including secondary hyperparathyroidism.
  • Intervention studies on calcium and vitamin D supplementation in the elderly are considered.

Main Results:

  • Elderly individuals often exhibit reduced calcium and vitamin D intake, sunlight exposure, and impaired vitamin D synthesis and absorption.
  • Secondary hyperparathyroidism is a common consequence, contributing to increased bone loss.
  • Alterations in calcium and vitamin D metabolism are central to age-related osteoporosis.

Conclusions:

  • Metabolic changes related to calcium and vitamin D are widespread in the aging population.
  • These alterations play a key role in the development of senile osteoporosis.
  • Optimizing calcium intake and maintaining adequate serum 25-hydroxyvitamin D3 levels are recommended preventive measures for the elderly.

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