Receptor-like protein tyrosine phosphatases: alike and yet so different

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Updated: Oct 31, 2026

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
09:40

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes

Published on: September 28, 2018

R Schaapveld1, B Wieringa, W Hendriks

  • 1Department of Cell Biology & Histology, Institute of Cellular Signalling, University of Nijmegen, The Netherlands.

Molecular Biology Reports
|December 24, 1997
PubMed

Insights

Reversible tyrosine phosphorylation regulates cell growth and differentiation. This review overviews identified receptor-like protein tyrosine phosphatase (RPTPase) family members and their biological roles.

Area of Science:

  • Molecular Biology
  • Cellular Signaling

Background:

  • Reversible phosphorylation on tyrosine residues is a rapid posttranslational modification crucial for cellular signaling.
  • This modification regulates key processes such as cell growth and differentiation.
  • The receptor-like protein tyrosine phosphatase (RPTPase) family plays a significant role in these signaling pathways.

Purpose of the Study:

  • To provide an overview of the molecular data for identified RPTPase family members.
  • To discuss the potential biological implications of these RPTPases.

Main Methods:

  • Molecular cloning techniques were utilized to identify RPTPase family members.
  • A review of existing molecular data was conducted.

Main Results:

  • An increasing number of RPTPase family members have been identified.
  • Molecular data for these RPTPases are becoming available.

Conclusions:

  • RPTPases are a significant family of enzymes involved in cellular regulation.
  • Further research into their molecular characteristics and biological functions is warranted.

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