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Related Experiment Videos

[Anesthesia in two patients with essential thrombocythemia]

Y Okada1, H Hino, H Nagahama

  • 1Department of Anesthesiology, St. Marianna University School of Medicine, Kawasaki.

Masui. the Japanese Journal of Anesthesiology
|December 24, 1997
PubMed
Summary

Essential thrombocythemia (ET) patients undergoing surgery can benefit from gabexate mesilate (GM), an antiplatelet agent. GM administration during anesthesia may prevent thrombocythemia-related complications like myocardial or pulmonary infarction.

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Area of Science:

  • Anesthesiology
  • Hematology
  • Pharmacology

Context:

  • Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts.
  • Patients with ET undergoing surgical procedures face increased risks of thromboembolic events.
  • Anesthetic management in ET patients requires careful consideration to mitigate perioperative complications.

Purpose:

  • To evaluate the safety and efficacy of gabexate mesilate (GM) as an antiplatelet agent in patients with essential thrombocythemia undergoing surgery.
  • To assess the impact of GM on platelet activation markers and thromboembolic risk during anesthesia and surgery in ET patients.

Summary:

  • Two cases of essential thrombocythemia patients undergoing surgery (laparotomy and gastrectomy) are presented.

Related Experiment Videos

  • Gabexate mesilate (GM), an antiplatelet agent, was administered perioperatively in both cases.
  • In Case 2, GM infusion during anesthesia led to a decrease in platelet factor 4 (PF-4) levels, a marker of platelet activation.

    • Impact:

    • Perioperative administration of gabexate mesilate may be a viable strategy to reduce the risk of thrombotic complications in essential thrombocythemia patients.
    • Monitoring platelet-releasing factors like PF-4 can help assess the effectiveness of antiplatelet therapy during surgery.
    • This approach could potentially prevent serious adverse events such as myocardial or pulmonary infarction in high-risk ET patients.