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Elevated post-prandial gastric inhibitory polypeptide concentrations in hypertriglyceridaemic subjects
1Department of Clinical Biochemistry, Royal Surrey County Hospital, Guildford, U.K.
Clinical Science (London, England : 1979)
|December 24, 1997
Summary
Hypertriglyceridaemic individuals exhibit elevated gastric inhibitory polypeptide (GIP) levels after meals, correlating with triglyceride levels. Glucagon-like peptide-1 (GLP-1) levels remained unchanged, suggesting GIP plays a role in hypertriglyceridaemia.
Area of Science:
- Endocrinology
- Metabolic Research
- Gastroenterology
Background:
- Hypertriglyceridaemia is often associated with hyperinsulinaemia.
- The roles of incretin hormones, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), in hypertriglyceridaemia are not fully understood.
Purpose of the Study:
- To investigate the potential contribution of GIP and GLP-1 abnormalities to hypertriglyceridaemia and hyperinsulinaemia.
Main Methods:
- Measured serum triglycerides, plasma glucose, GIP, GLP-1, and immunoreactive insulin (IRI) before and after a mixed meal.
- Compared levels between 15 hypertriglyceridaemic patients and 8 healthy controls.
Main Results:
- Hypertriglyceridaemic subjects showed higher integrated post-prandial GIP concentrations compared to controls.
- GIP levels positively correlated with both fasting and post-prandial triglyceride concentrations.
- Fasting and post-prandial IRI levels were elevated in hypertriglyceridaemic subjects and correlated with triglyceride levels.
- GLP-1 concentrations were similar between groups.
Conclusions:
- Hypertriglyceridaemic individuals exhibit post-prandial hyperGIPaemia alongside hyperinsulinaemia.
- No direct association was found between GIP and insulin levels.
- A significant association exists between post-prandial GIP concentrations and triglyceride levels, potentially involving lipoprotein lipase activity.
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