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Related Experiment Videos

Anaphylactic reactions to ingested carmine (E120)

B Wüthrich1, M K Kägi, W Stücker

  • 1Department of Dermatology, University Hospital, Zurich, Switzerland.

Allergy
|December 24, 1997
PubMed
Summary

Anaphylactic reactions to carmine (E120) can occur after consuming alcoholic beverages. Allergy testing for carmine is recommended for patients experiencing reactions after meals or drinks.

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Area of Science:

  • Food Science
  • Immunology
  • Allergy Research

Background:

  • Carmine (E120), a natural red dye derived from cochineal insects, is widely used in food and cosmetics.
  • Anaphylaxis is a severe, potentially life-threatening allergic reaction.
  • Identifying triggers for anaphylaxis is crucial for effective management and prevention.

Observation:

  • Five patients experienced anaphylactic reactions after consuming an alcoholic beverage containing carmine.
  • Skin prick tests (SPT) and RAST tests for carmine were positive in these patients.
  • One non-atopic patient demonstrated significant serum IgE antibodies to a carmine-albumin conjugate.

Findings:

  • The cases establish IgE-mediated sensitization to carmine as a cause of anaphylaxis.
  • The presence of IgE antibodies confirms an allergic immune response to carmine.
  • Carmine allergy can occur even in individuals without a history of atopy.

Implications:

  • Carmine should be considered as a potential allergen in patients with unexplained anaphylaxis, particularly after food or beverage consumption.
  • Routine allergy work-up should include testing for carmine in suspected cases.
  • Increased awareness among healthcare professionals regarding carmine as an allergen is warranted.

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