[Effect of dextran of 250.000 molecular weight on experimental cholesterin-sclerosis in rabbits]

Effect of dextran of 250000 molecular weight on experimental cholesterin-sclerosis of rabbits was studied. Doses of 120 (mg/week) kg and 1200 (mg/week) kg administered during 12 weeks have resulted a protective effect. When doses of 1200 (mg/week) kg have been administered--in the aortic adventitia intensive cellular reaction, no hitherto described was revealed, which was considered to be a sing of the exhaustion of RES. This publication authors regard as a preliminary one. To clear whether the cellular reaction observed is a dextran-specific or macro-moleculespecific one further investigations are needed.