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Related Experiment Videos

Melatonin modulates vascular smooth muscle tone

C D Mahle1, G D Goggins, P Agarwal

  • 1Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.

Journal of Biological Rhythms
|December 24, 1997
PubMed
Summary

Melatonin receptors are found in blood vessels, and melatonin can constrict arteries. Further research is needed to understand melatonin

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Cardiovascular Research

Background:

  • Molecular cloning of melatonin receptors has renewed interest in melatonin's actions.
  • Melatonin's diverse effects extend to the central nervous system and periphery.
  • Radioligand 2-[125I]iodomelatonin identifies melatonin binding sites in various species.

Purpose of the Study:

  • To investigate the localization of melatonin binding sites in rat caudal and cerebral arteries.
  • To examine the in vitro effects of melatonin on vascular tone in different arteries.
  • To highlight the need for selective receptor ligands to characterize melatonin's vascular actions.

Main Methods:

  • Localization of 2-[125I]iodomelatonin binding sites in rat arteries.
  • In vitro studies on the concentration-dependent effects of melatonin on arterial vasoconstriction.
  • Analysis of melatonin's impact on cerebral blood flow in rats.

Main Results:

  • Melatonin binding sites were identified in rat caudal and cerebral arteries.
  • Melatonin induced concentration-dependent vasoconstriction in rat, pig, and human coronary arteries in vitro.
  • Melatonin has been shown to reduce cerebral blood flow in rats.

Conclusions:

  • Melatonin influences vascular tone, with binding sites and vasoconstrictive effects observed in arteries.
  • The lack of selective receptor antagonists/agonists hinders full pharmacological characterization.
  • Further studies are warranted to elucidate the physiological role of melatonin in vascular tone modulation.

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