Mucosal defense of the outer eye
Related Experiment Video
Updated: Oct 31, 2026

Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
1Department of Ophthalmology, University of Sydney, Sydney Eye Hospital, Australia.
Abstract:
A combination of mechanical, anatomical, immunological, and microbiological factors prevent infection of the outer eye. Mechanical and anatomical factors include the intact epithelium of the conjunctiva and cornea and the constant blinking action of the eyelids. Tear components that play a role in eye defense include lysozyme, immunoglobulins, lactoferrin, and betalysin. The normal bacterial flora of the conjunctiva may also have an inhibitory effect on the survival of more pathogenic species. The eye is linked to the common mucosal immune system, thus gaining the benefits of a system of microbial defense which is primed in the gastrointestinal tract, where a continuing large antigen load is capable of stimulating ongoing immune protection. The relative roles of the various factors contributing to prevention of eye infection remain to be fully defined.
Related Concept Videos
Surface Membrane Barriers
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
Microbiome of the Eye
Accessory Structures of the Eye
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Defense Mechanism Against Infection
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Anatomy of the Eyeball
