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Soft tissue angiomyolipoma. A case report
H Mahera1, N Giamarelou, V Karabela-Bouropoulou
1Department of Pathology, State Regional General Hospital KAT, Kifissia, Greece.
Summary
A rare soft tissue angiomyolipoma in a lower extremity was initially misdiagnosed as a lipoma. Recurrence led to re-evaluation, revealing distinct histologic features requiring differentiation from sarcomas.
Area of Science:
- Oncology
- Pathology
- Dermatology
Background:
- Angiomyolipomas are typically found in the kidney but can occur in soft tissues.
- Deep soft tissue tumors present diagnostic challenges, especially when mimicking benign lesions.
Observation:
- A 79-year-old woman presented with a deep soft tissue tumor of the lower extremity.
- The initial tumor was diagnosed as a lipoma, but a recurrent tumor showed concerning histologic features.
Findings:
- The recurrent tumor exhibited extensive fibroplasia and atypical fibroblasts, mimicking malignancy.
- Histologic re-evaluation of the initial tumor confirmed it as an angiomyolipoma.
- The changes in the recurrent tumor were attributed to host reaction and degeneration.
Implications:
- This case highlights the importance of considering angiomyolipoma in deep soft tissue tumors.
- Distinguishing these changes from liposarcoma or leiomyosarcoma is critical for appropriate patient management.
- Accurate diagnosis requires careful histologic examination and consideration of clinical recurrence.

