Dynamic pituitary testing in a female with Kallman's syndrome and associated cardiac anomaly

A patient with Kallman's syndrome and an anomalous right aortic arch is described. Dynamic pituitary testing was carried out revealing no significant response of prolactin to chlorpromazine stimulation or water loading suppression. A normal response of growth hormone to insulin induced hypoglycemia was observed. These data are interpreted as indicating a primary hypothalamic abnormality in Kallman's syndrome. In addition, this is the first report of the association of a cardiovascular abnormality with Kallman's syndrome.