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Related Experiment Videos

Immunopotentiating compounds from Tinospora cordifolia

A Kapil1, S Sharma

  • 1Pharmacology Division, Regional Research Laboratory, Jammu Tawi, India.

Journal of Ethnopharmacology
|December 24, 1997
PubMed
Summary

Active compounds from Tinospora cordifolia, including syringin and cordiol, show anticomplementary and immunomodulatory effects. These compounds inhibit the complement pathway and enhance both humoral and cell-mediated immunity.

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Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Tinospora cordifolia is a traditional Indian medicinal plant.
  • Its active principles are investigated for biological activities.

Purpose of the Study:

  • To identify and characterize the anticomplementary and immunomodulatory activities of Tinospora cordifolia active principles.
  • To elucidate the mechanism of action of these compounds on the immune system.

Main Methods:

  • In vitro immunohaemolysis assay using antibody-coated sheep erythrocytes and guinea pig serum.
  • Assessment of complement pathway inhibition, specifically C3-convertase.
  • Measurement of serum IgG antibody levels.
  • Evaluation of humoral and cell-mediated immunity.

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  • Macrophage activation assays with varying incubation times.

    • Main Results:

    • Syringin (TC-4) and cordiol (TC-7) inhibited in vitro immunohaemolysis by targeting the classical complement pathway's C3-convertase.
    • Higher concentrations of these compounds exhibited sustained inhibitory effects.
    • Significant dose-dependent increases in serum IgG antibodies were observed.
    • Humoral and cell-mediated immunity were dose-dependently enhanced.
    • Cordioside (TC-2), cordiofolioside A (TC-5), and cordiol (TC-7) demonstrated dose-dependent macrophage activation, more pronounced with longer incubation.

    Conclusions:

    • Tinospora cordifolia contains active compounds with significant anticomplementary and immunomodulatory properties.
    • These compounds modulate the classical complement pathway and enhance both humoral and cellular immune responses.
    • The findings support the traditional use of Tinospora cordifolia and suggest its potential as an immunomodulatory agent.