Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early ritonavir-induced maculopapular eruption

C Bachmeyer1, L Blum, F Cordier

  • 1Département de Médecine Interne, Centre Hospitalier Laennec, Creil, France.

Dermatology (Basel, Switzerland)
|January 1, 1997
PubMed
Summary

Two human immunodeficiency virus (HIV) patients experienced rash and fever after starting ritonavir, a protease inhibitor. This suggests ritonavir can cause adverse skin reactions in HIV-infected individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive Observations of Magnetospheric Particle Acceleration, Sources, and Sinks (COMPASS): A Mission Concept to Explore the Extremes of Jupiter's Magnetosphere.

Space science reviews·2026
Same author

Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design.

bioRxiv : the preprint server for biology·2026
Same author

Diffuse, IDH-wildtype gliomas in adults with minimal histological change and isolated TERT promoter mutation: not simply CNS WHO grade 4.

Acta neuropathologica·2024
Same author

Salvage strategy for long-term central venous catheter-associated Staphylococcus aureus infections in children: a multi-centre retrospective study in France.

The Journal of hospital infection·2024
Same author

[Evaluation of a referral protocol to primary health care for patients eligible for health service access points following hospitalization].

Revue d'epidemiologie et de sante publique·2023
Same author

Non-invasive cell-free DNA prenatal screening for trisomy 21 as part of primary screening strategy in twin pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2023

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pharmacology

Background:

  • Human immunodeficiency virus (HIV) infection requires antiretroviral therapy, including protease inhibitors.
  • Ritonavir is a commonly used protease inhibitor in HIV treatment regimens.

Observation:

  • Two patients with HIV developed maculopapular eruption and fever within 2 days of initiating ritonavir therapy.
  • One patient showed improvement despite continuing ritonavir, while the second experienced symptom remission upon discontinuation and recurrence upon rechallenge.

Findings:

  • Ritonavir can induce adverse cutaneous reactions, such as maculopapular eruption and fever, in HIV-infected patients.
  • The reaction appears to be dose- or drug-dependent, as evidenced by the rechallenge in the second patient.

Related Experiment Videos

Implications:

  • Clinicians should consider ritonavir as a potential cause of cutaneous adverse drug reactions in HIV patients.
  • Monitoring for skin manifestations is crucial when initiating ritonavir therapy in this population.
  • This finding expands the known spectrum of adverse reactions associated with protease inhibitors.