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Related Experiment Videos

Tissue response to fast-setting calcium phosphate cement in bone

Y Miyamoto1, K Ishikawa, M Takechi

  • 1First Department of Oral and Maxillofacial Surgery, School of Dentistry, Tokushima University, Japan.

Journal of Biomedical Materials Research
|January 4, 1998
PubMed
Summary

Fast-setting calcium phosphate cement (FSCPC) offers rapid bone regeneration and excellent biocompatibility, making it superior to conventional calcium phosphate cement (c-CPC) for surgical applications.

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Area of Science:

  • Biomaterials Science
  • Surgical Innovation
  • Tissue Engineering

Background:

  • Conventional calcium phosphate cement (c-CPC) has limitations due to its slow setting time.
  • Fast-setting calcium phosphate cement (FSCPC) offers a significantly reduced setting time of 5-6 minutes.
  • Rapid setting is crucial for specific surgical applications.

Purpose of the Study:

  • To evaluate the tissue response and biocompatibility of FSCPC in rat tibiae.
  • To compare the in vivo conversion rate of FSCPC to hydroxyapatite (HAP) with c-CPC.
  • To assess the osteoconductivity and inflammatory potential of FSCPC.

Main Methods:

  • FSCPC and c-CPC were implanted into rat tibiae.
  • In vivo conversion to HAP was monitored over time.

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  • Infrared spectroscopy analyzed surface deposition.
  • Histological examination assessed tissue response and new bone formation.

    • Main Results:

    • FSCPC converted to HAP faster than c-CPC within the first 6 hours.
    • 100% conversion to HAP was achieved for FSCPC within 8 weeks.
    • B-type carbonate apatite deposition was observed on FSCPC surfaces.
    • Histology showed similar tissue response to c-CPC, with new bone formation and minimal early inflammation.
    • No resorption by osteoclasts or macrophages was observed for either cement within 8 weeks.

    Conclusions:

    • FSCPC demonstrates superior clinical applicability over c-CPC due to its faster setting time and early mechanical strength.
    • FSCPC exhibits excellent biocompatibility and osteoconductivity, comparable to c-CPC.
    • The rapid setting and favorable biological properties make FSCPC ideal for oral and maxillofacial, orthopedic, plastic, and reconstructive surgeries.