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Assessment of structure and function in progressive renal disease
L Agodoa1, G Eknoyan, J Ingelfinger
1Division of Kidney, Urologic and Hematologic Diseases, NIDDK, NIH, Bethesda, Maryland, USA. AGODOAL@EP.NIDDK.NIH.GOV
Kidney International. Supplement
|January 4, 1998
Summary
End-stage renal disease (ESRD) is increasing in the US. Early detection and interventions like blood pressure control are crucial for slowing disease progression and improving patient outcomes.
Area of Science:
- Nephrology
- Epidemiology
- Internal Medicine
Background:
- Rising incidence and prevalence of end-stage renal disease (ESRD) in the United States.
- Estimates suggest significant portions of the population have abnormal renal function, particularly African Americans.
- Progression rates are difficult to ascertain, but certain conditions like diabetes and lupus accelerate ESRD.
Purpose of the Study:
- To highlight the need for accurate assessment of early renal disease manifestations.
- To identify key predictors of disease progression.
- To explore effective interventions for slowing or halting ESRD progression.
Main Methods:
- Utilizing current assessment methods including serum creatinine, glomerular filtration rate, and proteinuria measurement.
- Employing radiologic imaging and histo-morphometry for structural and functional evaluation.
- Reviewing interventions such as hypertension control and ACE inhibitors.
Main Results:
- Current assessment methods for renal disease include functional and structural evaluations.
- Interventions like hypertension management and proteinuria reduction show promise in slowing progression.
- Further research is needed to identify definitive predictors and effective treatments.
Conclusions:
- Accurate assessment of early renal disease is vital for successful intervention.
- Hypertension control and proteinuria reduction are key strategies to slow ESRD progression.
- Continued clinical and basic science research is essential for advancing ESRD management.