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Aspirin effects on colonic mucosal bleeding: implications for colonic biopsy and polypectomy
H Nakajima1, H Takami, K Yamagata
1Department of Medicine, Kuroishi City Hospital, Hirosaki University School of Medicine, Aomori, Japan.
Diseases of the Colon and Rectum
|January 4, 1998
Summary
Aspirin significantly prolongs colon bleeding time, increasing risks during endoscopic procedures like biopsy and polypectomy. Colon bleeding time typically normalizes within two days after aspirin use.
Area of Science:
- Gastroenterology
- Endoscopy
- Hemostasis
Background:
- Patients undergoing endoscopic procedures often use antiplatelet agents.
- The impact of aspirin on colonic mucosal hemostasis requires further investigation.
Purpose of the Study:
- To evaluate the effect of aspirin on colonic mucosal bleeding time.
- To assess the safety and efficacy of a novel endoscopic device for measuring colon bleeding time.
Main Methods:
- A new endoscopic device was developed to create standard 7-mm incisions in the colonic mucosa.
- Colon bleeding time and skin bleeding time were measured in healthy subjects before and after aspirin ingestion (990 mg).
Main Results:
- Normal colonic mucosal bleeding time was established at 156 ± 71 seconds.
- Aspirin ingestion significantly prolonged both skin bleeding time (P < 0.05) and colon bleeding time (P < 0.05).
Conclusions:
- Colon bleeding time can be safely measured under direct colonoscopic visualization.
- Aspirin use increases the risk of abnormal bleeding during endoscopic biopsy and polypectomy.
- Colon bleeding time requires approximately two days to normalize in patients taking aspirin.