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Published on: October 21, 2014
Limited Wegener's granulomatosis with central nervous system involvement and fatal outcome
G Nordmark1, L Boquist, L Rönnblom
1Department of Internal Medicine, Boden Hospital, Umeå, Sweden.
Abstract:
A 74-year-old woman was admitted to the medical department with vertigo and confusion, and suffered seizures three days later. Clinical, radiological and histopathological examination revealed limited Wegener's granulomatosis (WG) with central nervous system (CNS) involvement. Initially she was treated successfully with prednisolone and cyclophosphamide, but she relapsed after 25 months and died four weeks later. Autopsy showed widespread granulomas with vasculitis in the cerebrum. These findings emphasize the importance of considering WG in CNS disease of unclear origin, and demonstrate the aggressive nature of the disease.
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