Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Approaches to informed consent

G Tognoni1, E Geraci

  • 1GISSI Coordinating Center, Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy.

Controlled Clinical Trials
|December 31, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of neutron efficiency and cross-talk effects through Monte Carlo simulations for a new neutron detector NArCoS.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

Functional propriospinal myoclonus in Alzheimer's disease: coincidence or a new challenge?

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2025
Same author

Evaluation of risk factors associated with acute kidney injury in a level IV regional NICU.

Journal of neonatal-perinatal medicine·2025
Same author

Qualitative evaluation of the Rey-Osterrieth Complex Figure Test in patients with progressive supranuclear palsy.

The Clinical neuropsychologist·2022
Same author

Association Between CSF Beta-Amyloid and Apathy in Early-Stage Alzheimer Disease.

Journal of geriatric psychiatry and neurology·2019
Same author

Endometriosis: seeking optimal management in women approaching menopause.

Climacteric : the journal of the International Menopause Society·2019
Same journal

On the generation and ownership of alpha in medical studies.

Controlled clinical trials·2004
Same journal

An analysis of the effect of funding source in randomized clinical trials of second generation antipsychotics for the treatment of schizophrenia.

Controlled clinical trials·2004
Same journal

Symptom recording in a randomised clinical trial: paper diaries vs. electronic or telephone data capture.

Controlled clinical trials·2004
Same journal

Statistical comparison of random allocation methods in cancer clinical trials.

Controlled clinical trials·2004
Same journal

Analyzing bronchodilation with emphasis on disease type, age and sex.

Controlled clinical trials·2004
Same journal

Geographic variability in patient characteristics, treatment and outcome in an International Trial of Magnesium in acute myocardial infarction.

Controlled clinical trials·2004
See all related articles

Informed consent (IC) is crucial but not the sole ethical component in clinical trials. Prioritizing patient rights and fostering well-informed decisions are key for ethical medical research and societal trust.

Area of Science:

  • Medical Ethics
  • Clinical Research
  • Patient Rights

Background:

  • Informed consent (IC) is central to clinical experimentation, particularly randomized controlled trials (RCTs).
  • The doctor-patient relationship and medicine's societal role are intertwined with IC.
  • Knowledge and power asymmetry persists even in experimental medical contexts.

Purpose of the Study:

  • To re-evaluate the role and significance of informed consent in clinical research.
  • To emphasize patient rights over procedural compliance in medical experimentation.
  • To explore alternatives and improvements for ensuring patient autonomy in decision-making.

Main Methods:

  • Conceptual analysis of informed consent within clinical practice and research.
  • Examination of the continuum between clinical investigation and standard care.

Related Experiment Videos

  • Discussion of documented, evaluable decisions as alternatives to individual IC.

    • Main Results:

    • Informed consent is often overemphasized, overshadowing more fundamental ethical considerations.
    • Patient rights are paramount and supersede regulatory compliance.
    • Well-informed decision-making processes are critical for the validity and credibility of IC.

    Conclusions:

    • Rethinking IC's role is essential for medicine's ethical self-perception and societal communication.
    • Documented decisions can substitute for individual IC when patients lack autonomy.
    • Improving IC practices can enhance medicine's responsiveness and public engagement.