Evolution of model proteins on a foldability landscape
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Updated: Oct 31, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
S Govindarajan1, R A Goldstein
1Department of Chemistry, University of Michigan, Ann Arbor 48109-1055, USA.
Abstract:
We model the evolution of simple lattice proteins as a random walk in a fitness landscape, where the fitness represents the ability of the protein to fold. At higher selective pressure, the evolutionary trajectories are confined to neutral networks where the native structure is conserved and the dynamics are non self-averaging and nonexponential. The optimizability of the corresponding native structure has a strong effect on the size of these neutral networks and thus on the nature of the evolutionary process.
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