Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improving interobserver variation in reporting gadolinium-enhanced MRI lesions in multiple sclerosis

F Barkhof1, M Filippi, J H van Waesberghe

  • 1Department of Diagnostic Radiology, Academic Hospital of the Vrije Universiteit, Amsterdam, The Netherlands.

Neurology
|December 31, 1997
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Measurements of the exclusive decays of the upsilon(5S) to meson final states and improved B(s)* mass measurement.

Physical review letters·2006
Same author

Charmonium Decays of Y(4260), psi(4160), and psi(4040).

Physical review letters·2006
Same author

Observation of Psi(3770)-->gammachi(c1)-->gammagammaJ/Psi.

Physical review letters·2006
Same author

MRI T2 lesion burden in multiple sclerosis: a plateauing relationship with clinical disability.

Neurology·2006
Same author

Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis.

Brain : a journal of neurology·2006
Same author

Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis.

Journal of neurology·2006

Observer training significantly improves the reporting of gadolinium-enhanced MRI lesions in multiple sclerosis (MS) patients. This enhances the reliability of MRI for monitoring disease activity in MS clinical trials.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Gadolinium-enhanced MRI is crucial for monitoring multiple sclerosis (MS) disease activity.
  • Assessing interobserver agreement in lesion reporting is vital for trial validity.

Purpose of the Study:

  • To evaluate interobserver agreement in reporting gadolinium-enhanced lesions in MS.
  • To determine the impact of observer training on reporting accuracy and agreement.

Main Methods:

  • Five experienced and five inexperienced radiologists evaluated serial MRI scans from 16 MS patients.
  • Scans were assessed before and after consensus formation and training.
  • Weighted kappa and mean average difference to the median (MADM) scores quantified agreement.

Related Experiment Videos

Main Results:

  • Training improved agreement for both experienced and inexperienced observers.
  • Experienced observers showed good agreement post-training for all lesion types.
  • Inexperienced observers showed moderate agreement for persistent lesions post-training.

Conclusions:

  • Observer training enhances interobserver agreement in reporting gadolinium-enhanced lesions.
  • Improved agreement validates serial enhanced MRI as an outcome measure in MS treatment trials.