Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and

W M Deng1, M Bownes

  • 1Institute of Cell and Molecular Biology, University of Edinburgh, UK.

Development (Cambridge, England)
|December 31, 1997
PubMed
Summary

The Broad-Complex gene is crucial for Drosophila dorsal appendage formation. Two signaling pathways coordinate its expression, guiding appendage development along major axes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Value of radiomics models based on MRI diffusion weighted imaging and apparent diffusion coefficient in differentiating benign and malignant thyroid nodules].

Zhonghua yi xue za zhi·2023
Same author

Optimising diffusion-weighted imaging of the thyroid gland using dedicated surface coil.

Clinical radiology·2022
Same author

[The efficacy of the improved tongue base suspension surgery combined with UPPP in the treatment of severe OSA].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2019
Same author

[Efficacy of Yisaipu tapering in the treatment of ankylosing spondylitis].

Zhonghua yi xue za zhi·2018
Same author

Daughters from daughterless mothers - Rescuing a female-lethal maternal effect by cytoplasmic transplantation inDrosophila embryos.

Wilhelm Roux's archives of developmental biology·2017
Same author

Temperature sensitivity ofTumorous head, a homoeotic mutant ofDrosophila melanogaster.

Wilhelm Roux's archives of developmental biology·2017

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Signaling

Background:

  • Drosophila eggshell morphogenesis involves precise patterning.
  • Dorsal appendages are key structures with asymmetric placement.

Purpose of the Study:

  • Investigate the genetic and signaling mechanisms controlling dorsal appendage formation.
  • Determine the role of the Broad-Complex in eggshell patterning.

Main Methods:

  • Analysis of gene expression patterns in Drosophila oogenesis.
  • Study of signaling pathways including EGF and TGF-β.
  • Genetic analysis of transcription factor function.

Main Results:

  • Broad-Complex (BR-C) is essential for dorsal appendage morphogenesis.

Related Experiment Videos

  • BR-C expression is regulated by two distinct signaling pathways.
  • Epidermal Growth Factor Receptor (EGFR) pathway specifies dorsoventral patterning.
  • Transforming Growth Factor-beta (TGF-β) pathway refines anterior-posterior localization.

    • Conclusions:

    • Coordinated signaling pathways precisely position follicle cells for appendage development.
    • BR-C acts as a key transcription factor downstream of these pathways.
    • This study elucidates a model for signal-instructed morphogenesis in Drosophila.