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Related Experiment Videos

[Paternal age and fertility]

J F Guérin1, J de Mouzon

  • 1Faculté de médecine, Laboratoire d'Histologie, Embryologie, Biologie de la Reproduction, Lyon.

Contraception, Fertilite, Sexualite (1992)
|July 1, 1997
PubMed
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Male fertility shows minimal age-related changes, with sperm concentration and normal forms remaining stable. While motility declines, sperm fertilizing capacity and overall pregnancy rates are largely unaffected by paternal age.

Area of Science:

  • Reproductive Medicine
  • Andrology
  • Human Fertility Studies

Background:

  • Assessing male fertility variations with age is challenging due to confounding factors like female fecundity decline.
  • Previous research indicates stable sperm concentration and normal forms, with only motility showing a consistent age-related decrease.
  • Sperm's fertilizing capacity appears resilient to aging.

Purpose of the Study:

  • To investigate the impact of male age on semen parameters and fertility outcomes.
  • To analyze large-scale in vitro fertilization (IVF) data to confirm age-related semen alterations.
  • To evaluate the relationship between paternal age, fertilization rates, and pregnancy success.

Main Methods:

  • Analysis of approximately 30,000 IVF cycles from the FIVNAT database, focusing on cases of tubal sterility.

Related Experiment Videos

  • Statistical evaluation of semen parameters (sperm concentration, normal forms, motility) in relation to male age.
  • Correlation of fertilization and pregnancy rates with maternal age, considering paternal age effects.

    • Main Results:

    • Semen characteristics, including sperm concentration and percentage of normal forms, remain largely stable with increasing male age.
    • Sperm motility shows a systematic decrease with advancing paternal age.
    • Despite a moderate decrease in mean fertilization rates, overall pregnancy rates remained constant for specific maternal age groups.

    Conclusions:

    • Paternal age has a limited impact on overall semen quality and fertilizing capacity.
    • IVF data confirm that significant alterations in semen characteristics due to male aging are not prevalent.
    • While fertilization rates may slightly decrease, successful pregnancy rates are maintained, suggesting male age is not a primary barrier to conception in IVF.